Future development of biosensors

Sensor development Key sensors and instrument components are among the most basic components of instrumentation and automation systems. Sensors and instrumentation components are characterized by a wide range of services, a wide variety of products, and a large demand. The improvement of their technological level and product quality will lay the foundation for China's manufacturing informatization. But market demand determines that we must take a strategic route.

1. Focus on industrial control, automotive, communications, and environmental protection as the key service areas, and focus on sensors, flexible components, optical components, and special circuits to develop original technologies and products with independent intellectual property rights;

2. Based on MEMS technology, relying on integrated, intelligent and networked technologies to strengthen the manufacturing process and the development of new sensors and instrument components, leading the leading products to reach and reach the advanced level of similar foreign products;

3, to increase the variety, improve quality and economic efficiency as the main goal, accelerate industrialization, so that the domestic sensor and instrument components of the species share of 70% to 80%, high-end products up to 60%.

The sensor market is very large, but companies can only develop themselves better by grasping firmly and let them run smoothly under this big market. Only in this way can a company stand out from the top and grow stronger and weaker and stronger.

The instrumentation industry has shown rapid development in recent years. A statistical data from the China Instrument and Meter Association indicated that the production and sales of China's instrumentation industry continued to rise after rising at a high rate of two years. In the first half of 2007, the total output value of China's instrumentation industry was 133.5 billion yuan, an increase of 29.1% year-on-year; the sales revenue of products was 1289. Billion yuan, a year-on-year increase of 30.7%, both at historically high levels; profits increased by more than 40% year-on-year, total assets increased by about 18% year-on-year, and the industry as a whole is in a healthy development phase.

In the first half of the year, the demand structure of the four major specialty products has changed significantly. There are many products in the field of instrumentation, industrial automation instrumentation and control systems are still higher than the growth rate of the whole industry, and the growth in production and sales is 34%, reflecting that China is still in the period of rapid development of energy and heavy chemical industry, but the increase rate is 38% higher than the previous year. The decline shows that structural adjustments in thermal power, metallurgy and other applications have had an impact. Environmental monitoring instruments increased by 40% year-on-year, reflecting the demand for related instruments for environmental governance, energy saving and emission reduction. Optical instruments, supply instruments, testing machines, geological exploration and special instruments for earthquakes, teaching instruments and other products maintained an average increase in the industry. Electrical instrumentation, surveying and mapping instruments, test and analysis instruments, automotive instrumentation, navigation, meteorological marine instruments, nuclear measurement instruments, electronic measuring instruments, timing instruments, weighing instruments, medical instruments, etc., are lower than the industry average, and the demand for some products is stable. The production capacity is too large; some products have large technological gaps, and the middle-to-high end product market is occupied by imported products, and the problem of structural adjustment is obvious.

The location changed quietly. Beijing, Tianjin, Shanghai, and other major cities were once the birthplace and concentration area of ​​China's instrumentation industry. They have good conditions and are among the best in the long term. With the changes in the regional industrial structure, although the foundation is good but the growth is not fast, in the first half of this year, it was about 10%. The scale of production and sales in Beijing and Shanghai has already relegated to the fifth and sixth place in the country. The Su, Yue, Zhe, and Lu are later on, and their output value has surpassed Beijing and Shanghai. Jiangsu and Guangdong provinces have gathered foreign capital. The instrumentation industry accounts for a relatively large proportion and has leapt to the first and second place in the instrumentation industry in the provinces and cities. In recent years, private enterprises in Zhejiang have developed rapidly and have formed regional industrial clusters. The large quantity of products with a wide range of products forms large-scale production, and it also has a model of industrialization of high-tech achievements, ranking third in the country.

Instrumentation breakthroughs in major projects export growth, import growth is small. In the first half of the year, China's instrumentation industry increased exports by 36.4%. Industrial automation instrumentation systems, electronic measuring instruments, testing machines, laboratory analysis instruments, medical instruments, and other export growth rates were all above 40%. Industrial automation instruments and electronic measurements that had not been exported in the past were large. The increase in instrumentation was as high as 76.9% and 104.5%, respectively, and some products such as pressure/differential pressure transmitters, semiconductor component testing and communication instruments, precision balances, spectrophotometers, and X-ray inspection instruments have multiplied. In traditional export products, electricity meters, gas meters, optical components, telescopes, microscopes, thermometers, etc. did not increase significantly except for the 65.5% increase in water meters. The increase in imports has dropped to 7.2%. Optical instruments, most electrical instrumentation, and medical instruments have turned negative.

What is particularly encouraging is that the decentralized control system, as an important product of the instrumentation industry, continues to make breakthroughs in key national projects. In January 2007, the decentralized control system developed by Beijing Guodian Zhiyuan Co., Ltd. was successfully put into operation in the 600MW subcritical unit of Longshan Power Plant, Hebei Province, and it entered commercial operation; in August 2007, it was also a 600MW supercritical unit in Liaoning Zhuanghe Power Plant. Put into operation successfully. Zhejiang Zhonghua’s decentralized control system with independent intellectual property rights successfully bid for the 300,000 T synthetic ammonia/520000 T urea project at Lunan Fertilizer Plant; in April 2007, it also signed four Sinopec Wuhan refining projects with 5 million T/year. The master device provides the control system. The above breakthrough will effectively break the monopoly of foreign companies in the national key projects for important instrumentation, control devices and automation systems.

In the second half of the year, the growth rate will slowly decline. In the second half of the year, the instrumentation industry will continue its trend for the first half of the year. Demand, production and sales are still at high levels, but the increase will slow down. It is expected that the growth rate of production and sales will be slightly higher than the previous year or basically the same. Due to the relatively indirect and lagging response of the instrumentation industry to the macroeconomics, some product growth will fall back to next year. In the overall stable development trend in the second half of the year, it will have the following characteristics:

Industrial automation instrumentation and control devices and environmental monitoring and analysis instruments have the fastest growth, and other instruments and instruments will not change their stable growth trend. In the country's implementation of circular economy, environmental protection, emission reduction, high-efficiency, energy saving, "large pressure small" and other policies and measures, thermal power, metallurgy, building materials and other medium-sized devices and "five small businesses" and other demand for instruments will be significantly reduced. The large-scale, complex and new application fields of industrial devices and the requirements of their devices will cause domestic companies to face many problems such as product technology level, application adaptability, and entry barriers. Foreign companies have comparative advantages and will have an impact on the market structure. .

There are two different situations in which corporate profits are changing. On the one hand, due to the increase in proficiency in production and the increase in the technological content of products, some companies increase their labor productivity and increase their profit margins. On the other hand, due to rising raw material prices, labor costs, and utility costs. , exchange rate changes and other reasons, a lot of product costs rise, the production capacity of middle and low-end products in domestic companies, middle-grade products in foreign-funded enterprises and foreign and domestic companies in the increasingly fierce price competition, some companies have profit There are signs of decline.

Instruments and meters broke through major projects: “The rapid growth of exports and the small increase in imports” will not change in the second half of the year. From the high growth of exports that has lasted for many years, the basis is the improvement of the technological level and the acceleration of industrial development. Another important factor this year is the company's response to the macroeconomic situation. Both foreign-funded enterprises and competitive enterprises in China are using existing facilities to increase their export intensity in order to cope with the possible slowdown in the domestic economy. In the first half of the year, the value of export delivery accounted for 28.6% of the total industrial output value, which was a year-on-year increase of 41.3%. In fact, the growth rate of the industry-wide industry was higher than that of export growth in the same period of last year. The increase in domestic market was basically the same. In exports, the increase in commissioned foreign capital production is evident. Due to the wide disparity between the bases of import and export, the import and export deficit will still be as high as US$8 billion, but this year may be the first year since China’s reform and opening up.

When it comes to breakthroughs in major projects in China's instrumentation industry, Yan Jiacheng has dubbed it "a step ahead in tough times," and the promotion and improvement of instrumentation has been on the agenda. The application of important instrumentation and control systems in major projects will be from point to point. Products that break through will be expanded from single DCS types to other important products, from single products to wider areas and more complex devices, and breakthrough products have been promoted. Further improvement of its level will be the focus of work in the second half of the year.

The full-scale development of biosensor research was in the 1980s and has grown rapidly over the past 20 years. It has been highly valued and widely used in food industry, environmental monitoring, fermentation industry, and medicine.

Biosensors The four major application areas of biosensors are entering a period of comprehensive in-depth research and development, and a growing number of miniaturized, integrated, intelligent, and practical biosensors and systems.

1. Applications of food industry biosensors in food analysis include analysis of food ingredients, food additives, harmful toxins, and food freshness.

Food composition analysis: In the food industry, glucose content is an important indicator of fruit maturity and shelf life. The developed enzyme electrode biosensor can be used to analyze glucose in white wine, apple juice, jam and honey.

Analysis of Food Additives: Sulfites are commonly used as bleaching agents and preservatives in the food industry, and current-type sulfur dioxide electrodes made using sulphite oxidase as a sensitive material can be used to determine the content of sulfurous acid in foods. In addition, the use of biosensors for the determination of pigments and emulsifiers has also been reported.

2. Environmental Monitoring In recent years, the problem of environmental pollution has become increasingly serious. People are eager to have an instrument capable of continuous, rapid, and on-line monitoring of pollutants. Biosensors meet people's requirements. At present, a considerable part of biosensors have been used in environmental monitoring.

Atmospheric environment monitoring: Sulfur dioxide (SO2) is the main reason for the formation of acid rain and the traditional detection method is very complicated. Marty et al. immobilized subcellular lipids on cellulose acetate membranes and oxygen electrodes to make amperometric biosensors for the detection of acid rain acid mist sample solutions.

3. Fermentation industry Among various biosensors, microbial sensors have the characteristics of low cost, simple equipment, no limitation on the degree of turbidity of the fermentation broth, and elimination of interference from interfering substances in the fermentation process. Therefore, microbial sensors are widely used as an effective measurement tool in the fermentation industry.

Microbial sensors can be used to measure raw materials and metabolites in the fermentation industry. In addition, it is also used to determine the number of microbial cells. The use of this electrochemical cell number sensor allows continuous and on-line determination of cell concentration.

4. Biosensors in the medical field are playing an increasingly larger role. Biosensing technology not only provides a rapid and simple new method for basic medical research and clinical diagnosis, but also has broad application prospects in military medicine because of its uniqueness, sensitivity, and quick response.

In clinical medicine, enzyme electrodes are the earliest developed and most widely used sensors. Microbial sensors can be made using microorganisms with different biological properties instead of enzymes. In military medicine, yes. The prompt and rapid detection of com biotoxins is an effective measure to prevent biological weapons. Biosensors have been used to monitor a wide variety of bacteria, viruses and their toxins.

Several characteristics of biosensors in the future In recent years, with the development of bioscience, information science and material science, biosensor technology has developed rapidly. It can be foreseen that future biosensors will have the following features.

Diversification of functions: Future biosensors will further involve medical care, disease diagnosis, food testing, environmental monitoring, and various fields of the fermentation industry. At present, one of the important contents of biosensor research is to study biosensors that can replace the biological senses of vision, hearing, and touch, ie bionic sensors.

Miniaturization: With the advancement of microfabrication technology and nanotechnology, biosensors will continue to be miniaturized, and the emergence of various portable biosensors will enable people to diagnose diseases at home, making it possible to directly detect foods in the market.

Intelligent and integrated: In the future, biosensors must be tightly integrated with computers, automatically collect data and process data, provide scientific and more accurate results, realize sampling, sample injection, and result-completion, and form an automated detection system. At the same time, more and more chip technologies will enter the sensor field to realize the integration and integration of detection systems.

Low cost, high sensitivity, high stability, and long lifespan: The continuous advancement of biosensor technology will inevitably require continuous reduction of product cost, increase of sensitivity, stability, and prolong life. Improvements in these characteristics will also accelerate the commercialization and commercialization of biosensors.

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